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KMID : 0383820060610050440
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Tuberculosis and Respiratory Diseases
2006 Volume.61 No. 5 p.440 ~ p.446
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Clinical Characteristics of Tuberculosis in Liver or Heart Trans-plant Recipients
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Jung Hoon
Oh Yeon-Mok
Lee Sang-Do
Kim Woo-Sung
Kim Dong-Soon
Kim Won-Dong
Kim Jae-Joong
Lee Sung-Gyu
Shim Tae-Sun
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Abstract
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Background: Post-transplant tuberculosis (TB) is a serious complication in solid organ transplant recipients worldwide, However there is little or no data on TB in liver or heart transplant recipients in Korea.
Methods: The incidence and clinical characteristics of TB of 730 patients who had undergone a liver transplant in a university hospital in Korea between 1992 and 2004, and 110 heart transplant recipients in the same period, were reviewed retrospectively.
Results: The incidence of TB was 1.5%(11/730) and 2.7%(3/110) in the liver and heart transplantation, respectively. The median time from the transplant to the development of TB was 8.4 months(1.0-30.8). and the mean time from the symptoms to the diagnosis of TB was 2.1±3.6 months(0.3-13.2). Nine patients (65%) had pulmonary TB and five (35%) had extrapulmonary TB. The leukopenia and positive HbeAg at the baseline, post-transplant diabetes mellitus, and chronic rejection were associated with the development of TB in the liver transplant recipients. Ten patients were treated with a 4-drug standard regimen for a mean duration of 7.8±3.5 months. One patients died of TB.
Conclusion: The incidence of TB in liver or heart transplant recipients was similar to that reported in other countries with a similar TB-burden. (Tuberc Respir Dis 2006; 61: 440-446)
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KEYWORD
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Tuberculosis, Liver transplantation, Heart transplantation
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